Chloramphenicol Loaded Sponges Based on PVA/Nanocellulose Nanocomposites for Topical Wound Delivery

In the present study, polymer sponges based on poly(vinyl alcohol) (PVA) were prepared for topical wound administration of chloramphenicol (CHL), an antibiotic widely used to treat bacterial infections. Nanocellulose fibrils (CNF) homogenously dispersed in PVA three different ratios (2.5, 5, and 10 wt %) improve mechanical properties neat sponges. Infrared spectroscopy showed hydrogen bond formation between CNF PVA, while scanning electron microscopy photos verified successful dispersion The addition successfully enhanced sponges, exhibiting higher compressive strength as content increased. sponge containing % CNF, due its compression strength, was further studied a matrix CHL delivery 10, 20, 30 concentration drug. X-ray diffraction that encapsulated amorphous state 20 samples, some crystallinity observed ratio. vitro dissolution studies solubility after incorporation PVA/10 Release profiles controlled release lasting days sample 1.5 other two samples. According modelling, is driven by pseudo-Fickian diffusion.